Olanzapine, cytochrome p45 and tobacco smoke

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  • Reynard
    Member
    • Feb 2009
    • 804

    Olanzapine, cytochrome p45 and tobacco smoke

    Hi guys,

    I've been snusing again for a couple of months and thought I'd post a problem i had whilst smoking. Smoking affects (reduces) the blood plasma concentration of Olanzapine (a antipsychotic prescription drug I take) by up to 40%. It is due to an enzyme cytochrome p45 that is present in tobacco smoke (and grapefruit juice!). I used to have real problems when I quit smoking in the past and had a massive resurgence of Olanzapine in my system, and prior to quite recently did not have a clue as to why (I thought it was nicotine causing the problem). It was only when I researched it that this mechanism became clear. Now I'm back on snus there is no problem.

    If you're on any kind of medicine, always do your homework as regards interactions!
  • clint404
    Member
    • Jul 2011
    • 317

    #2
    Grapefruit juice has something to to with monoamine oxidase inhibitors. I know this from past mdma, and dxm use by my brother.

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    • ABW
      Member
      • May 2011
      • 793

      #3
      Grapefruit can cause all kids of issues... The biggest being decreased drugs metabolite execration.. In other words you can have overdose on certain drugs if they are used with grapefruit products...

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      • sgreger1
        Member
        • Mar 2009
        • 9451

        #4
        Yah same goes with people using benzo's. Can't eat grapefruit whilst taking Xanax, probably shouldn't smoke either. Like always, Snus comes through.

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        • Reynard
          Member
          • Feb 2009
          • 804

          #5
          Like always, Snus comes through.
          Couldn't have out it better myself! +1

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